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ELECTRON MICROSCOPIC STUDY OF THE PASSAGE A MOUSE LEUKEMIA VIRUS IN MAMMARY GLANDS OF PREGNANT, VIRUS-INJECTED, C3H(F) MICE.
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1963
Year
Maternal ImmunizationElectron Microscopic StudyMammary GlandsVirus ParticlesPathogenesisImmunologyViral PathogenesisPathologyVirologyMammary GlandElectron MicroscopeMammary Gland BiologyMedicineAnimal VirusMammary Gland Development
Summary Ultrathin sections of mammary glands from four pregnant C3H(f) females with passage A virus-induced leukemia were examined with the electron microscope and revealed the presence of a considerable number of virus particles similar in appearance to those observed in other organs of leukemic mice. Particles often seemed continuous with the cell membrane of the mammary epithelium, apparently in the process of budding. When mammary glands of five pregnant, virus-injected, but nonleukemic, C3H(f) females were examined, virus particles, generally in smaller quantities than in the leukemic mice, were found in three out of five mice examined. No particles were observed in the mammary glands of three healthy pregnant and two lactating C3H(f) females that had not been given injections of the virus.