Heart Failure with Preserved Ejection Fraction Induces Molecular, Mitochondrial, Histological, and Functional Alterations in Rat Respiratory and Limb Skeletal Muscle

Abstract

Our findings are the first to demonstrate that HFpEF induces significant molecular, mitochondrial, histological, and functional alterations in the diaphragm and soleus, which were attenuated by exercise training. These data therefore reveal novel mechanisms and potential therapeutic treatments of exercise intolerance in HFpEF.