Sensory hyperinnervation and increase in <scp>NGF</scp>, <scp>TRPV1</scp> and <scp>P2X₃</scp> expression in the epidermis following cast immobilization in rats

Abstract

The time course of the increase in peripheral nerve fibres and in the expression of TRPV1 and P2X3 paralleled the development of hypersensitivity, which suggests that histological changes of the skin following cast immobilization may have some relation to the resulting hypersensitivity.