Studies on radiation-induced leukemia in mice.

Abstract

Fractionated total-body x radiation of young adult mice of C3H, C57BR/ cd, A, and I strains induced leukemia in up to 77 per cent of the irradiated mice after a latency varying from 5 to 6 months. Fractionated total-body irradiation of mice of the high-leukemic Ak strain had practically no effect on the incidence of spontaneous leukemia. A group of C3H mice were inoculated when newborn with Ak or C3H leukemia filtrates and then irradiated. The incidence of leukemia in this group was 43 per cent, as compared with 33 per cent in the litter-mate control group which received only the inoculation of the agent. (auth)