Formation of Phosphorylated 3<i>H</i>‐Pyrroles from <i>Nef</i>Isocyanide<i>Perkow</i> Adducts and Tosylmethyl Isocyanide

Abstract

Abstract Imidoyl chlorides, generated from isocyanides and acyl chlorides, react with trialkyl phosphites, in a Perkow ‐type reaction, to afford 3‐(alkylimino)‐2‐[(dialkyloxyphosphoryl)oxy]acrylates, which undergo a smooth reaction with tosylmethyl isocyanide (TsMIC) to furnish 4‐(alkylamino)‐3‐[(dialkyloxyphosphoryl)oxy]‐5‐[(4‐methylphenyl)sulfonyl]‐3 H ‐pyrrole‐3‐carboxylates in moderate‐to‐good yields.