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Comparative in Vitro Studies on Effector Cell Diversity in the Cellular Immune Response to Murine Sarcoma Virus (MSV)-Induced Tumors in Mice
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1974
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ImmunologyImmunoeditingImmunologic MechanismSarcoma VirusRelease TestT CellsImmunotherapyTumor BiologyTumor ImmunityRadiation OncologyAutoimmunityT Cell ImmunityCell BiologyTumor MicroenvironmentCancer ImmunosurveillanceEffector Cell DiversityCellular Immune ResponseMedicineViral OncologyViral ImmunityMurine Sarcoma Virus
Abstract The cellular immune response to murine sarcoma virus (MSV)-induced tumors in B6 mice was studied in vitro with two techniques: the 51Cr release test (CRT) and the microcytotoxicity assay (MA). The analysis of the effector cell nature in each of these assays showed that only thymus-dependent (T) cells are effector cells in CRT, while both T and non-T cells can be effector cells in MA. Comparative studies of the same lymphoid cell preparations demonstrated that the T cells revealed in MA might not be identical with the T cells whose activity is measured in CRT.