Comparison of effect of gamma ray irradiation on wild-type and N-terminal mutants of αA-crystallin.

Abstract

Our findings suggest that the N-terminal mutants of αA-crystallin are structurally and functionally more sensitive to GI when compared to their NGI counterparts and wt. Protein oxidation as a result of gamma irradiation drives the protein to cross-link and aggregate culminating in cataract formation.