Dose requirement and prolactin elevation of antipsychotics in male and female patients with schizophrenia or related psychoses

Abstract

Patients on long-term antipsychotic therapy, with doses adjusted according to therapeutic efficiency, exhibited hyperprolactinaemia and elevated BMI, but no obvious influence on the GH-IGF-I axis. Furthermore, it appeared that the males required twice the dose of antipsychotic compared with females.