Inhibition of capsaicin‐driven nasal hyper‐reactivity by <scp>SB</scp>‐705498, a <scp>TRPV</scp>1 antagonist

Abstract

Intranasal SB-705498 has an appropriate safety and PK profile for development in humans and achieves clinically relevant attenuation of capsaicin-provoked rhinitis symptoms in patients with NAR. The potential impact intranasal SB-705498 may have in rhinitis treatment deserves further evaluation.