Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow‐transit constipation

Abstract

There are age-related reductions in nerve fiber density in human colon circular muscle. NOS and VIP do not show regional variations, while SP nerve fiber density is higher in distal colon. 1/3 of pediatric STC patients have low SP or VIP nerve fiber density in proximal colon.