Publication | Open Access
Synthesis of 3', 4'-Dideoxybutirosin A, Active against Butirosin Resistant Bacteria
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1974
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Bioorganic ChemistrySecondary MetaboliteButirosin Resistant BacteriaAntimicrobial ChemotherapyAntibiotic ResistancePharmaceutical ChemistryDrug ResistanceMedicinal ChemistryBiosynthesisSelective ToxicityAntimicrobial ResistanceBiochemistryAntibacterial AgentAntimicrobial CompoundPharmacologyNatural SciencesSynthesized 3Butirosin-resistant MicroorganismsMicrobiologyMedicineAcute Toxicity
In order to overcome butirosin-resistant microorganisms of 3'-O-phosphorylation type, 3', 4'-dideoxybutirosin A (2) was synthesized according to the method of Umezawa, et al. The synthesized 3', 4'-dideoxy derivative (2) exhibited significant activities agaisnt both butirosin-sensitive and resistant strains in vitro and in vivo and its acute toxicity was found to be at a similar level to that of butirosin.