PubMed · 1964 · 81 citations · 0 references
Veterinary MedicineOncologyVeterinary OncologyGastrointestinal OncologyImmunotherapyTumor ImmunologyMalignant NeoplasmsMalignant TumorsRodent OncologyCell LysisClostridial InfectionsClostridial SporesIntratumoral AdministrationOncologic Transplantation
Treatment of transplanted tumors of the hamster with nonpathogenic clostridia were reported. The intravenously injected spores germinated in the tumors and produced within very few days an extensive or complete lysis of the tumor. A cure or increase in survival time has not been obtained so far. The possibilities and limitations of this novel biological tumor treatment have been discussed.