Inhibition of endothelial cell <scp><scp>Ca</scp>²⁺</scp> entry and transient receptor potential channels by <scp>S</scp>igma‐1 receptor ligands

Abstract

The data suggest that two types of Sig1R ligand (BD1047/BD1063 and 4-IBP) are inhibitors of receptor- or chemically activated calcium entry channels, acting relatively directly and independently of the Sig1R. Chemical foundations for TRP channel inhibitors are suggested.