Seasonal pasture myopathy/atypical myopathy in <scp>N</scp> orth <scp>A</scp> merica associated with ingestion of hypoglycin <scp>A</scp> within seeds of the box elder tree

Abstract

For the first time, SPM has been linked to a toxin in seeds abundant on autumn pastures whose identified metabolite, MCPA, is known to cause acquired MADD, the pathological mechanism behind SPM and AM. Further research is required to determine the lethal dose of hypoglycin A in horses, as well as factors that affect annual seed burden and hypoglycin A content in Acer species in North America and Europe.