Complement activation, endothelin‐1 and neuropeptide Y in relation to the cardiovascular response to endotoxin‐induced systemic inflammation in healthy volunteers

Abstract

A dose of endotoxin associated with reproducible systemic vasodilation and fever in healthy subjects causes complement activation and increased systemic levels of ET-1-LI, illustrating that the model is a useful tool for inducing moderate systemic inflammation where several mediator systems are activated.