Contribution to the Biginelli Reaction, using a Bentonitic Clayas Catalyst and a Solventless Procedure

Abstract

The reaction of a set of five aldehydes, ethyl acetoacetate and urea or thiourea (Biginelli reaction) has been performed over a bentonitic clay as the catalyst, under solventless conditions using infrared irradiation as the energy source, obtaining the corresponding dihydropyrimidones .