Anxiolytic‐like and anxiogenic‐like effects of nicotine are regulated via diverse action at<scp>β</scp>2*nicotinic acetylcholine receptors

Abstract

These studies provide direct evidence that low-dose nicotine inhibits nAChRs and demonstrate that inhibition or stimulation of β2*nAChRs supports the corresponding anxiolytic-like or anxiogenic-like effects of nicotine. Inhibition of β2*nAChRs may relieve anxiety in smokers and non-smokers alike.