Carcinogenicity of 1, 2-benzanthracene.

Abstract

Summary Carcinogenic activity of moderate potency has been demonstrated by five different specimens of 1,2-benzanthracene as tested by sarcoma induction in C57 black mice following subcutaneous injection. The carcinogenic index (Iball) varied from 18.5 down to 2.6. The minimal tumor dose was not determined, because the smallest amount tested (0.05 mg/mouse) was above the tumor threshold dose. Reference is made to the importance of these observations to carcinogens, mutagens, and to other biological phenomena.