Asymmetric Diastereoselective Synthesis of Spirocyclopropane Derivatives of Oxindole

Abstract

Abstract A new asymmetric organocatalytic synthesis of spirocyclopropane oxindoles has been developed. The method is based on the Michael addition of N ‐Boc‐protected 3‐chlorooxindole to unsaturated 1,4‐dicarbonyl compounds, affording trans ‐substituted spirocyclopropane oxindole derivatives in high diastereo‐ and enantioselectivity.