Inhibitory Effect of D-Glucosamine and Other Sugars on the Biosynthesis of Protein, Ribonucleic Acid, and Deoxyribonucleic Acid in Normal and Neoplastic Tissues

Abstract

The effect of exogenous glucosamine on the incorporation of lysine-14 C, uridine-1 4 C, and thymidine-4 C into various normal and experimental tumor tissues was studied. Glucosamine at high concentrations markedly inhibited the incorporation of these precursors into protein, RNA, and DNA of Walker carcinosarcoma 256 of rats and of sarcoma 180 and C3H spontaneous mammary tumor of mice. Glucose or pyruvate did not reverse the inhibition by glucosamine.