Long‐Range Diastereoselectivity in an Ugi Reaction: Stereocontrolled and Diversity‐Oriented Synthesis of Tetrahydrobenzoxazepines

Abstract

Abstract Salicylaldehydes and protected 1,2‐amino alcohols have been convergently converted into a series of 2,3‐dihydrobenzo[ f ][1,4]oxazepines, which undergo an Ugi–Joullié multicomponent reaction with unusual long‐range diastereoselectivity. This protocol allows the diastereoselective preparation, in only two steps, of a series of drug‐like tetrahydrobenzo[ f ][1,4]oxazepines, with the combinatorial introduction of four diversity points. The possibility of obtaining these compounds in enantiomerically pure form was also demonstrated.