Uncoupling protein‐2 mediates the protective action of berberine against oxidative stress in rat insulinoma <scp>INS</scp>‐1<scp>E</scp> cells and in diabetic mouse islets

Abstract

Berberine inhibited oxidative stress and restored insulin secretion in HG-treated INS-IE cells and diabetic mouse islets by activating AMPK and UCP2. UCP2 is an important signalling molecule in mediating anti-diabetic effects of berberine.