PRIMARY AND SECONDARY GOUT

Abstract

Article1 November 1953PRIMARY AND SECONDARY GOUTALEXANDER B. GUTMAN, M.D., F.A.C.P.ALEXANDER B. GUTMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-5-1062 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is now some indication that the clinical syndrome of gout may well comprise several distinct anomalies of purine metabolism.1 Of these at least one may properly be considered a primary form of gout, the others as secondary to some other disease, usually involving the hematopoietic system.Primary goutis the common category of the disorder, and is more widespread than is often appreciated. As suspected by Garrod,2gout (in its primary form) may be classified as an inborn error of purine metabolism.3Recent surveys4-6of asymptomatic members of the families of patients with overt gout have revealed so high...Bibliography1. GutmanYü ABTF: Gout, a derangement of purine metabolism, Advances Int. Med. 5: 227, 1952. MedlineGoogle Scholar2. Garrod AE: The inborn factors in disease, 1931, Clarendon Press, Oxford. CrossrefGoogle Scholar3. Neel JV: The clinical detection of the genetic carriers of inherited disease, Medicine 26: 115, 1947. CrossrefMedlineGoogle Scholar4. Talbott JH: Serum urate in relatives of gouty patients, J. Clin. Investigation 19: 645, 1940. CrossrefMedlineGoogle Scholar5. SmythCottermanFreyberg CJCWRH: The genetics of gout and hyperuricemia—an analysis of nineteen families, J. Clin. Investigation 27: 749, 1948. CrossrefGoogle Scholar6. StecherHershSolomon RMAHWM: The heredity of gout and its relationship to familial hyperuricemia, Ann. Int. Med. 31: 595, 1949. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented (in part) at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 16, 1953.This work was supported by a grant-in-aid from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health.From The Department of Medicine, The Mount Sinai Hospital, and the Department of Medicine, Columbia University College of Physicians and Surgeons, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDo Serum Urate–associated Genetic Variants Influence Gout Risk in People Taking Diuretics? 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CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.On the biosynthesis of uric acid from glycine-N15 in primary and secondary polycythemiaControl of pain in metastatic cancerSome observations on 520 gouty patientsBasic Sciences in Relation to Rheumatic DiseasesGouty Arthritis—Diagnosis and Treatment 1 November 1953Volume 39, Issue 5Page: 1062-1076KeywordsArthritisGoutHospital medicineMetabolic disordersPurinesSurgeons Issue Published: 1 November 1953 PDF downloadLoading ...