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Immunological studies of anthrox. II. Levels of immunity against Bacillus anthracis obtained with protective antigen and live vaccine.
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1962
Year
Humoral ResponseImmunologyImmune SystemNon-host ResistanceDisease ResistanceLive VaccineImmunity IndexInfection ControlHost-pathogen InteractionsMicrobial ToxinVaccine DevelopmentVaccine TestingImmune FunctionHost-microbe InteractionBacillus AnthracisClinical MicrobiologyProtective AntigenVaccinationMicrobiologyHost ResistanceMedicineVaccine Research
Summary Levels of resistance to challenge with spores of a virulent strain of Bacillus anthracis were measured by means of an immunity index. The immunizing effect of protective antigen alone produced a level of resistance approximately 1000-fold greater than that of controls. The effect of protective antigen and a supplemental injection of live vaccine was 100,000,000-fold. Live vaccine alone produced only a 10- to 15-fold increase in resistance.