Amitriptyline up‐regulates connexin43‐gap junction in rat cultured cortical astrocytes via activation of the <scp>p</scp>38 and <scp>c</scp>‐<scp>Fos</scp>/<scp>AP</scp>‐1 signalling pathway

Abstract

These findings indicate a novel mechanism of action of amitriptyline through cortical astrocytes, and further suggest that targeting this mechanism could lead to the development of a new class of antidepressants.