EFFECTS OF FLUORIDE ACCUMULATION ON SOME ENZYMES OF BRAIN AND GASTROCNEMIUS MUSCLE OF MICE

Abstract

cantly (p<0.01) in both brain and gastrocnemius muscle. The effect of fluoride on enzymes of muscle was comparatively larger, which corroborates the greater accumulation of fluoride in muscle than brain. This study therefore shows that both brain and muscle are affected by fluoride with inhibition of some enzymes associated with free-radical metabolism, energy production and transfer, membrane transport, and synaptic transmission, but with an en- hanced activity of XOD.