Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils

Abstract

Collectively, these findings provide new insight into host defense in the cornea and the pathogenesis of HSV-1 infection by identifying previously unacknowledged MCs as protective innate sentinels for infection of the ocular surface and reinforcing that neutrophils are detrimental to corneal infection.