DEATH DUE TO WITHDRAWAL OF BARBITURATES

Abstract

Case Reports1 June 1953DEATH DUE TO WITHDRAWAL OF BARBITURATESH. F. FRASER, M.D., M. R. SHAVER, M.D., E. S. MAXWELL, M.D., H. ISBELL, M.D., F.A.C.P.H. F. FRASER, M.D., M. R. SHAVER, M.D., E. S. MAXWELL, M.D., H. ISBELL, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-6-1319 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough it is known that abrupt withdrawal of barbiturates from persons who have been chronically intoxicated with large amounts of these drugs may precipitate a serious abstinence syndrome,1, 2a review of the American literature revealed no report in which death was attributed to abstinence from barbiturates. Three cases in which death was associated with withdrawal of barbiturates were found in the German literature. Two of these cases were complicated by the presence of organic disease (Buerger's disease with gangrene, and acute yellow atrophy of the liver with blood dyscrasia), so that abstinence from barbiturates could be regarded only as...Bibliography1. PohlischPanse KF: Schlafmittelmissbrauch, 1934, Georg Thieme, Leipzig. Google Scholar2. IsbellAltschulKornetskyEisenmanFlanaryFraser HSCHAJHGHF: Chronic barbiturate intoxication, Arch. Neurol. and Psychiat. 64: 1, 1950. CrossrefMedlineGoogle Scholar3. Meyer HJ: Über chronischen Schlafmittelmissbrauch und Phanodorn Psychosen, Psychiat.-neurol. Wchnschr. 41: 275, 1939. Google Scholar4. FraserIsbell HFH: Unpublished data. Google Scholar5. SeeversTatum MHAL: Chronic experimental barbital poisoning, J. Pharmacol. and Exper. Therap. 42: 217, 1931. Google Scholar6. FraserIsbell HFH: Unpublished data. Google Scholar7. McCrumIngramBoylan WRWRRG: Histology of the brain and blood in chronic experimental sedation with barbiturates and Presidon, Proc. Soc. Exper. Biol. and Med. 78: 193, 1951. CrossrefMedlineGoogle Scholar8. MottWoodhousePickworth FWDLMB: The pathological effects of hypnotic drugs upon the central nervous system of animals, Brit. J. Exper. Path. 7: 325, 1926. Google Scholar9. Isbell H: Addiction to barbiturates and the barbiturate abstinence syndrome, Ann. Int. Med. 33: 108, 1950. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. F. FRASER, M.D.; M. R. SHAVER, M.D.; E. S. MAXWELL, M.D.; H. ISBELL, M.D., F.A.C.P.*Received for publication December 13, 1952.From the National Institute of Mental Health, Addiction Research Center, Public Health Service Hospital, Lexington, Kentucky. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDependence, withdrawal and rebound of CNS drugs: an update and regulatory considerations for new drugs developmentBenzodiazepines and BarbituratesBarbiturate withdrawal-a nomogram for supplementary dosing after the phenobarbitone loading techniqueMechanisms of Benzodiazepine Drug DependenceBarbiturate, analgesic, and caffeine withdrawalSubstance WithdrawalQuazepam: Hypnotic Efficacy and Side EffectsClinical Consequences of Abrupt Drug WithdrawalRebound Insomnia and Elimination Half-Life: Assessment of Individual Subject ResponseClinical Comparison of Benzodiazepine Hypnotics With Short and Long Elimination Half-LivesThe Phenomenological Structure of Drug-Induced Ego States. II. Barbiturates and Sedative-Hypnotics: Phenomenology and ImplicationsGeneral Problems of Drug Abuse and Drug DependenceThe Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of ActionThe Assessment of the Abuse Potentiality of Sedative/Hypnotics (Depressants) (Methods Used in Animals and Man)WITHDRAWAL PSYCHOSIS: A STUDY OF 30 CONSECUTIVE CASESForensische ToxikologieA free clinic approach to drug abuseDrogenabhängigkeitenOutpatient Barbiturate Withdrawal Using PhenobarbitalTreatment Techniques for Narcotic Withdrawal With Special Reference to Mixed Narcotic-Sedative AddictionsA New Method of Outpatient Treatment of Barbiturate WithdrawalClinical and Experimental Aspects of Barbiturate Withdrawal ConvulsionsPharmacology of Hypnotic AgentsPhysiological Aspects of Tolerance and Physical Dependence 1 June 1953Volume 38, Issue 6 Page: 1319-1325 Keywords Atrophy Blood Drugs Liver Liver diseases Medical services Psychiatry and mental health ePublished: 1 December 2008 Issue Published: 1 June 1953 PDF downloadLoading ...