SPLENIC INFARCTION IN SICKLEMIA DURING AIRPLANE FLIGHT: PATHOGENESIS, HEMOGLOBIN ANALYSIS AND CLINICAL FEATURES OF SIX CASES

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Article1 February 1956SPLENIC INFARCTION IN SICKLEMIA DURING AIRPLANE FLIGHT: PATHOGENESIS, HEMOGLOBIN ANALYSIS AND CLINICAL FEATURES OF SIX CASESROYAL ROTTER, WILLIAM F. LUTTGENS, WESLEY L. PETERSON, ALBERT E. STOCK, ARNO G. MOTULSKY, M.D.ROYAL ROTTERSearch for more papers by this author, WILLIAM F. LUTTGENSSearch for more papers by this author, WESLEY L. PETERSONSearch for more papers by this author, ALBERT E. STOCKSearch for more papers by this author, ARNO G. MOTULSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-2-257 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvidence has accumulated that individuals with sicklemia, when exposed to decreased oxygen tension during airplane flight, may develop infarction of the spleen. In 1950 Sullivan1described one case of sickle cell trait with sudden splenic enlargement following an airplane flight. Since that time several reports from military establishments have appeared in the literature which have confirmed the association of splenic infarction, sicklemia and airplane flight. Cooley, Peterson, Engel and Jernigan2reported six cases of massive splenic infarction in Negroes following air travel. Each individual was treated with splenectomy. Two more cases of splenic infarction in Negroes precipitated by aerial flight...Bibliography1. Sullivan BH: Danger of airplane flight to persons with sicklemia, Ann. Int. Med. 32: 338, 1950. LinkGoogle Scholar2. CooleyPetersonEngelJernigan JCWLCEJP: Clinical triad of massive splenic infarction, sicklemia trait, and high altitude flying, J. A. M. A. 154: 111, 1954. CrossrefMedlineGoogle Scholar3. Conn HO: Sickle-cell trait and splenic infarction associated with high-altitude flying, New England J. Med. 251: 417, 1954. 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SmithConley EWCL: Filter paper electrophoresis of human hemoglobins with special reference to the incidence and clinical significance of hemoglobin C, Bull. Johns Hopkins Hosp. 93: 94, 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication June 4, 1955.From the Department of Medicine, University of Washington, Seattle, Washington, and the U. S. Army and Air Force.†This investigation was supported in part by research grants from Initiative 171, State of Washington, and the U. S. Public Health Service, Contract H-1519. 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HETTIG, M.D.Clinical Picture of Sickle-cell Disease 1 February 1956Volume 44, Issue 2Page: 257-270KeywordsArmed forcesHemoglobinHypoxiaInfarctionMedical servicesOxygenPathogenesisResearch grantsSpleenSplenectomy ePublished: 1 December 2008 Issue Published: 1 February 1956 PDF downloadLoading ...