Long‐term effects of melatonin on quality of life and sleep in haemodialysis patients (<scp>M</scp>elody study): a randomized controlled trial

Abstract

The high drop-out rate limits the strength of our conclusions. However, although a previous study reported beneficial short term effects of melatonin on sleep in haemodialysis patients, in this long-term study the positive effects disappeared during follow up (6-12 months). Also the quality of life parameter, vitality, did not improve. Efforts should be made to elucidate the mechanism responsible for the loss of effect with chronic use.