Fungal metabolites. II. Structural elucidation of minor metabolites, valinotricin, cyclonerodiol oxide, and epicyclonerodiol oxide, from Trichoderma polysporum.

Abstract

A new minor metabolite, valinotricin (1), along with cyclonerodiol oxide (9) and epicyclonerodiol oxide (10) was isolated from Trichoderma polysporum. The structure of valinotricin was elucidated as 1 by chemical and spectral studies, and then confirmed by synthesis. Chemical and spectroscopic studies of cyclonerodiol oxide and epicyclonerodiol oxide led to the structures 9 and 10, respectively.