Electrospun Polycaprolactone (PCL) and PCL/ nano-hydroxyapatite (PCL/nHA)-based nanofibers for bone tissue engineering application

Abstract

Ceramic/polymer composite scaffolds have been widely investigated for repairing and regeneration of damaged bone tissues. In this report, the electrospinning technique was chosen to fabricate two different kinds of fibrous scaffolds which were Polycaprolactone (PCL) and PCL/nano-hydroxyapatite (PCL/nHA). Several characterizations such as morphologies of fibers, average diameter and water uptake property were done. Based on the results obtained, PCL/nHA fibers with the average diameters of 521.10nm exhibited good water uptake properties and were more hydrophilic than pure PCL fibers. PCL/nHA-based nanofibers could be potential in bone tissue regeneration.