Intervirology · 1995 · 56 citations · 0 references
MedicineInfectious DiseasesOncologyCancer EpidemiologyEpidemiologyHepatologyCancer RiskEnvironmental Cancer EpidemiologyHepatobiliary DiseaseHepatocellular CarcinomaLiver DiseaseViral HepatitisEnvironmental Exposure FactorsEnvironmental FactorsEnvironmental HepatocarcinogenesisFamily Health HistoryHepatocellular Carcinoma PathogenesisLiver Cancer EpidemiologyProspective Case Study
To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.