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Secular trends (1990–2013) in serotypes and associated non-susceptibility of S. pneumoniae isolates causing invasive disease in the pre-/post-era of pneumococcal conjugate vaccines in Spanish regions without universal paediatric pneumococcal vaccination

VaccinationVaccine SafetyPneumococcal Conjugate VaccinesSecular TrendsEmerging Infectious DiseasesSpanish RegionsVaccine EfficacyInfection ControlMedicineVaccine ResearchClinical MicrobiologyEpidemiology