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STUDIES IN CYSTIC FIBROSIS: DETERMINATION OF SWEAT ELECTROLYTES IN SITU WITH DIRECT READING ELECTRODES
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1969
Year
Electrolyte DisorderMisleading ValueEngineeringBioanalysisPhysiologySkin SurfaceLaboratory MedicineElectrolyte DisturbanceAnalytical ChemistryElectrophysiologyBiomedical EngineeringClinical ChemistryDermatologySpecific-ion ElectrodesMedicine
An evaluation is made of newly developed specific-ion electrodes for determining sodium and chloride on the skin surface following the stimulation of the sweat glands by pilocarpine iontophoresis. This procedure offers a rapid (5 to 6 minutes), convenient, and safe means for large-scale cystic fibrosis screening programs for screening infants and children. Caution is urged in the evaluation of the reading since a failure to sweat may result in a misleading value.