Extracellular signal-regulated kinase activation predominantly in Müller cells of retina with endotoxin-induced uveitis.

Abstract

The present study suggests that LPS stimulation activates ERK in Müller cells, whereas the total amount of ERK is unchanged. Because the LPS-induced p-ERK level was reduced by Dex treatment, its expression seems to be associated with ocular inflammatory stimulus. Because the inflammatory stimulus elicited in EIU upregulated ERK activity in Müller cells, activated Müller cells may play a crucial role in protecting retinal cells from such inflammation.