Role of H₂O₂ in hypertension, renin‐angiotensin system activation and renal medullary disfunction caused by angiotensin II

Abstract

The renal medulla is a major target for Ang II-induced redox dysfunction. H(2) O(2) appears to be the key mediator enhancing intrarenal RAS activation and decreasing systemic RAS activity. The specific control of renal medullary H(2) O(2) levels may provide future grounds for the treatment of hypertension.