<scp>NS309</scp> decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating <scp>SK3</scp> channels

Abstract

Our data reveal that SK3 channel is the main SK/IK subtype in rat DSM. Pharmacological activation of SK3 channels with NS309 decreases rat DSM cell excitability and contractility, suggesting that SK3 channels might be potential therapeutic targets to control OAB associated with detrusor overactivity.