Intracellular distribution of uricase and catalase in livers of tumor-bearing mice and mice given injections of aminotriazole.

Abstract

1. The uricase activity of livers of tumor-bearing mice diminished with increasing tumor growth more slowly and ultimately less extensively than did the catalase activity. There was apparently no effect on the intracellular distribution of either enzyme. 2. Injection of 3-amino-1,2,4-triazole had no effect on uricase under conditions in which the liver catalase was reduced essentially to zero.