Intraperitoneal administration of tumor-targeting <i>Salmonella typhimurium</i> A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice

Abstract

Tumor-specific targeting of S. typhimurium A1-R was confirmed with bacterial culture from tumors and various organs and tumor or organ colony formation after i.v. or i.p. injection. Selective tumor targeting was most effective with i.p. administration. The results of the present study show S. typhimurium A1-R has promising clinical potential for disseminated ovarian cancer, especially via i.p. administration.