Pharmacological profile of opicapone, a third‐generation nitrocatechol catechol‐<scp><i>O</i></scp>‐methyl transferase inhibitor, in the rat

Abstract

Opicapone has a prolonged inhibitory effect on peripheral COMT, which extends the bioavailability of levodopa, without inducing toxicity. Thus, it exhibits some improved properties compared to the currently available COMT inhibitors.