Concepedia

Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.

Jessica Thompson, F J Schmidt, Eric Cundliffe

Journal of Biological Chemistry · 1982 · 147 citations · 15 references

DOIFull text

Open access

Concepts

Abstract

A methylase enzyme, responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton. This RNA-pentose methylase modifies adenosine-1067 of Escherichia coli 23 S rRNA.

References

15

Aminoglycoside Antibiotic-Inactivating Enzymes in Actinomycetes Similar to Those Present in Clinical Isolates of Antibiotic-Resistant Bacteria

Raoul Ė. Benveniste, Julian Davies · Proceedings of the National Academy of Sciences · 1973 · 507 citations · Full text

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Secondary structure model for 23S ribosomal RNA

Harry F. Noller, J Kop, V I Wheaton et al. · Nucleic Acids Research · 1981 · 380 citations · Full text

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Primary and secondary structures of Escherichia coli MRE 600 23S ribosomal RNA. Comparison with models of secondary structure for maize chloroplast 23S rRNA and for large portions of mouse and human 16S mitochondrial rRNAs

Christiane Branlant, Alain Krol, Mohamed Ali Machatt et al. · Nucleic Acids Research · 1981 · 227 citations · Full text

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Secondary structure of the large subunit ribosomal RNA from Escherichia coli, Zea mays chloroplast, and human and mouse mitochondrial ribosomes

Carola Glotz, Christian Zwieb, Richard Brimacombe et al. · Nucleic Acids Research · 1981 · 197 citations

, , +14

Genetics of industrial microorganisms

V. S. Malik · Nature · 1978 · 179 citations

, , +12