Contribution of Functional <i>LILRA3</i>, but Not Nonfunctional <i>LILRA3</i>, to Sex Bias in Susceptibility and Severity of Anti–Citrullinated Protein Antibody–Positive Rheumatoid Arthritis

Abstract

Our study provides the first evidence that functional LILRA3 is a novel genetic risk factor for RA, especially in males. It appears to highly predispose to ACPA-positive RA and confers an increased risk of disease severity in patients with early RA.