Simvastatin Effects on Androgens, Inflammatory Mediators, and Endogenous Pituitary Gonadotropins among Patients with PCOS Undergoing IVF: Results from a Prospective, Randomized, Placebo-Controlled Clinical Trial

Abstract

This report presents data from the first prospective, randomized, placebo-controlled clinical investigation of simvastatin in the setting of PCOS and IVF. Simvastatin seems to be compatible with gonadotropin therapy for IVF and can offer beneficial endocrine and cardiovascular effects for patients with PCOS who undergo embryo transfer. Although the observed improvements in reproductive function were mild, the reductions in hsCRP and vascular cell adhesion protein-1 after simvastatin treatment were significant, suggesting the need for further clinical trials to clarify simvastatin's impact on reproductive physiology.