Hypersensitivity to Ascaris antigens. 3. Atopic-type hypersensitivity induced in Rhesus monkeys.

Abstract

These studies indicate that crude Ascaris extract contains two components, separated by electrophoresis, with distinct biologic properties. The cathode migrating fraction 1) is nontoxic in guinea pigs, 2) induces wheal and flare reactions in normal animals, 3) elicits wheal and flare reactions in sensitized animals and 4) releases histamine from passively sensitized monkey lung tissue. The anode migrating fraction is toxic in guinea pigs and is unable to 1) sensitize normal animals, 2) elicit wheal and flare reactions in sensitized animals and 3) release histamine from passively sensitized lung tissue.