Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.

Abstract

Cartilage-inducing factors-A (CIF-A) and -B (CIF-B), purified from bovine bone on the basis of their ability to induce the cartilage phenotype in vitro, are proteins with molecular weights of 26,000 composed of two apparently identical disulfide-linked chains.CIF-A is apparently identical to TGF-8 from human platelets (Seyedin S.