Successful sequential liver-kidney transplantation in a patient with performed lymphocytotoxic antibodies.

Abstract

Sensitization of potential transplant recipients by formation of lymphocytotoxic antibodies can be a result of prior blood transfusions, pregnancy, or failed allograft transplantation. While the presence of preformed anti-HLA-A and -B lymphocytotoxic antibodies does not appear to influence the survival of liver allografts,1 this has been a contraindication in renal transplantation because of the high incidence of hyperacute rejection.2 We report a case of successful transplantation of a renal allograft, in the face of a positive warm T cell crossmatch sequentially following a prior hepatic allograft transplantation from the same donor.