Entacapone improves the availability of <scp>l</scp>‐dopa in plasma by decreasing its peripheral metabolism independent of <scp>l</scp>‐dopa/carbidopa dose

Abstract

The 200 mg dose of entacapone similarly and significantly increases the AUC of L-dopa by changing the metabolic balance of L-dopa independent of the L-dopa/carbidopa dose and therefore entacapone is likely to have a similar L-dopa potentiating effect independent of L-dopa dose.