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SUCCESSFUL TREATMENT OF RHESUS MONKEYS FOR SEPTICEMIC ANTHRAX
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References
1964
Year
Unknown Venue
Mucosal VaccinationSepticemic AnthraxAntibioticsImmunologyRespiratory ExposureSepsisInfectious Respiratory DiseaseAntimicrobial ChemotherapyInfection ControlMedicineClinical MicrobiologyAnti-infective AgentsAntimicrobial ResistanceActive Immunization
Abstract : Septicemic anthrax established by respiratory exposure has been effectively cured by a treatment combination of antibiotics, antiserum and active immunization during treatment protocol. The treatment protocol is based on the knowledge that death in anthrax is toxemic. Twenty-one of twenty-five monkeys administered these treatment combinations were cured and, by active immunization, were made completely resistant to anthrax upon rechallengingg aerogenically with h large doses of virulent spores. Of the four monkeys that died, only two died from anthrax and the remaining two from complications. This treatment regime is believed to hold great promise for application to man.