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Total synthesis of the antibiotic WS-5995A using a key reaction of o-toluamide anions with homophthalic anhydrides.
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1989
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Medicinal ChemistryEngineeringBiochemistryAnticoccidial Antibiotic Ws-5995aNatural SciencesTotal SynthesisOrganic ChemistryO-toluamide AnionsKey ReactionAntimicrobial CompoundChemistryPharmacologyDerivative (Chemistry)Synthetic ChemistryBiomolecular EngineeringNatural Product Synthesis
A total synthesis of the anticoccidial antibiotic WS-5995A was achieved by regioselective condensation of N, N-diethyl-o-toluamide anions into bomophthalic anhydrides as a key reaction.